Laboratory Burnt Out by small experiment
A small scale sealed tube chlorination of a pyrazole using POCl3
Few mgs of the pyrazole + 4ml of POCl3 in a 10ml sealed tube. Pop into a suitable oilbath at 220°C and leave overnight.
Top floor of Research buiding burned out
Cause and ActionsTube overpressurised (calculated pressure >300psig at 220°C - rated at 200psig at ambient), then POCL3 leaked from tube, igniting oil bath (with oil above its flash point).
Sealed tube reactions banned, clampdown on proper risk assessments